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Ligand · 7HP

7HP · 7-hydroxy-pyrazolo[4,3-d]pyrimidine

7HP, 7-hydroxy-pyrazolo[4,3-d]pyrimidine (C5 H4 N4 O, 136.1 g/mol), in the MolNFT structures on GenesisL1: bound in 14 records (7 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands…

Component
7HP
Formula
C5 H4 N4 O
Class
ligand
Structures
14
PDB entries
7

Binding sites

7HP in 14 structures; the first of them:

  • 1I0I · Analysis of an invariant aspartic acid in hprts-glutamine mutant · 7HP A800 · binds ILE113, GLN115, LYS143, ALA163, PHE164, VAL165, LEU170, ASP171
  • 1I0L · Analysis of an invariant aspartic acid in hprts-asparagine mutant · 7HP A800 · binds ILE113, ASN115, LYS143, ALA163, PHE164, VAL165, LEU170, ASP171
  • 1I13 · Analysis of an invariant aspartic acid in hprts-alanine mutant · 7HP A800 · binds ILE113, ALA115, LYS143, ALA163, PHE164, VAL165, LEU170, ASP171
  • 1I14 · Analysis of an invariant aspartic acid in hprts-glutamic acid mutant · 7HP A800 · binds ILE113, GLU115, LYS143, ALA163, PHE164, VAL165, LEU170, ASP171
  • 1P18 · Hypoxanthine Phosphoribosyltransferase from Trypanosoma cruzi, K68R mutant, ternary… · 7HP A800 · binds ILE113, ASP115, LYS143, ALA163, PHE164, VAL165, LEU170, ASP171
  • 1PVS · 3-methyladenine Glcosylase II(AlkA) Hypoxanthine complex · 7HP A800 · binds GLY123, GLN124, LEU125, VAL126, TRP218, ASP237, ASP238, TYR239
  • 1TC2 · Ternary substrate complex of the hypoxanthine phosphoribosyltransferase from trypanosoma… · 7HP A800 · binds ILE113, ASP115, LYS143, ALA163, PHE164, VAL165, LEU170, ASP171
  • 1I0I · Analysis of an invariant aspartic acid in hprts-glutamine mutant · 7HP A800 · binds ILE113, GLN115, LYS143, ALA163, PHE164, VAL165, LEU170, ASP171
  • 1I0L · Analysis of an invariant aspartic acid in hprts-asparagine mutant · 7HP A800 · binds ILE113, ASN115, LYS143, ALA163, PHE164, VAL165, LEU170, ASP171
  • 1I13 · Analysis of an invariant aspartic acid in hprts-alanine mutant · 7HP A800 · binds ILE113, ALA115, LYS143, ALA163, PHE164, VAL165, LEU170, ASP171
  • 1I14 · Analysis of an invariant aspartic acid in hprts-glutamic acid mutant · 7HP A800 · binds ILE113, GLU115, LYS143, ALA163, PHE164, VAL165, LEU170, ASP171
  • 1P18 · Hypoxanthine phosphoribosyltransferase from trypanosoma cruzi, K68R mutant, ternary… · 7HP A800 · binds ILE113, ASP115, LYS143, ALA163, PHE164, VAL165, LEU170, ASP171
  • 1PVS · 3-methyladenine glcosylase II(ALKA) hypoxanthine complex · 7HP A800 · binds GLY123, GLN124, LEU125, VAL126, TRP218, ASP237, ASP238, TYR239
  • 1TC2 · Ternary substrate complex of the hypoxanthine phosphoribosyltransferase from trypanosoma… · 7HP A800 · binds ILE113, ASP115, LYS143, ALA163, PHE164, VAL165, LEU170, ASP171

Residues it binds most

ASP 28, ALA 24, LEU 28, VAL 28, ILE 24, LYS 24, PHE 24, TYR 16, GLN 8, ASN 4 (residue and the binding sites it lines).

Found with

  • PRP · 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose
  • MG · Magnesium ion
  • MN · Manganese (II) ion
  • FMT · Formic acid

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