Ligand · 77D
77D · 2-[(2-fluoro-4-iodophenyl)amino]-5,5-dimethyl-8-oxo-N-[(3R)-piperidin-3-yl]-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepine-3-carboxamide
77D, 2-[(2-fluoro-4-iodophenyl)amino]-5,5-dimethyl-8-oxo-N-[(3R)-piperidin-3-yl]-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepine-3-carboxamide (C22 H26 F I N4 O2 S, 556.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…
- Component
- 77D
- Formula
- C22 H26 F I N4 O2 S
- Class
- ligand
- Structures
- 2
- PDB entries
- 1
Binding sites
77D in 2 structures; the first of them:
- 3SLS · Crystal Structure of human MEK-1 kinase in complex with UCB1353770 and AMPPNP · 77D A500 · binds ASN78, GLY79, GLY80, LYS97, ILE99, LEU101, LEU115, LEU118 and 9 more
- 3SLS · Crystal structure of human MEK-1 kinase in complex with UCB1353770 and amppnp · 77D A500 · binds ASN78, GLY79, GLY80, LYS97, ILE99, LEU101, LEU115, LEU118 and 9 more
Residues it binds most
LEU 4, GLY 4, ILE 4, VAL 4, ASP 4, ASN 4, LYS 4, MET 4, PHE 4, SER 4 (residue and the binding sites it lines).
Found with
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