Ligand · 778
778 · 4-[(5-{[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl}-1H-imidazol-1-yl)methyl]benzonitrile
778, 4-[(5-{[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl}-1H-imidazol-1-yl)methyl]benzonitrile (C22 H20 Cl N5 O, 405.9 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB entries). Every binding site with its…
- Component
- 778
- Formula
- C22 H20 Cl N5 O
- Class
- ligand
- Structures
- 6
- PDB entries
- 3
Binding sites
778 in 6 structures; the first of them:
- 1S63 · Human protein farnesyltransferase complexed with L-778,123 and FPP · 778 B3012 · binds TYR166, LEU96, SER99, TRP102, TRP106, ARG202, ASP297, CYS299 and 3 more
- 1S64 · Rat protein geranylgeranyltransferase type-I complexed with L-778,123 and a sulfate anion · 778 B380 · binds TYR166, ALA123, ARG173, PHE174, CYS177, GLN212, HIS219, GLY221 and 9 more
- 3Q7A · Cryptococcus neoformans protein farnesyltransferase in complex with FPP and L-778,123 · 778 B3012 · binds TYR109, LEU84, SER87, TRP90, TRP94, ARG197, ASP323, CYS325 and 3 more
- 1S63 · Human protein farnesyltransferase complexed with L-778,123 and fpp · 778 B3012 · binds TYR166, LEU96, SER99, TRP102, TRP106, ARG202, ASP297, CYS299 and 3 more
- 1S64 · Rat protein geranylgeranyltransferase type-I complexed with L-778,123 and a sulfate anion · 778 B380 · binds TYR166, ALA123, ARG173, PHE174, CYS177, GLN212, HIS219, GLY221 and 9 more
- 3Q7A · Cryptococcus neoformans protein farnesyltransferase in complex with fpp and L-778,123 · 778 B3012 · binds TYR109, LEU84, SER87, TRP90, TRP94, ARG197, ASP323, CYS325 and 3 more
Residues it binds most
CYS 16, TYR 16, HIS 16, TRP 16, ARG 16, ASP 16, LEU 16, SER 16, ALA 12, GLN 12 (residue and the binding sites it lines).
Found with
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