GL1X · GenesisL1 explorer

Ligand · 74F

74F · 3-(benzotriazol-1-yl)-5-[1-methyl-5-[(1~{S})-1-morpholin-4-ylethyl]-1,2,4-triazol-3-yl]pyrazin-2-amine

74F, 3-(benzotriazol-1-yl)-5-[1-methyl-5-[(1~{S})-1-morpholin-4-ylethyl]-1,2,4-triazol-3-yl]pyrazin-2-amine (C19 H22 N10 O, 406.4 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with…

Component
74F
Formula
C19 H22 N10 O
Class
ligand
Structures
4
PDB entries
2

Binding sites

74F in 4 structures; the first of them:

  • 5T23 · PI3Kg IN COMPLEX WITH 5d · 74F A1201 · binds MET804, TRP812, ILE831, LYS833, TYR867, ILE879, GLU880, ILE881 and 9 more
  • 5T27 · mPI3Kd IN COMPLEX WITH 5d · 74F A1101 · binds THR750, MET752, PRO758, TRP760, ILE777, LYS779, TYR813, ILE825 and 9 more
  • 5T23 · PI3KG in complex with 5D · 74F A1201 · binds MET804, TRP812, ILE831, ILE879, GLU880, ILE881, VAL882, ALA885 and 6 more
  • 5T27 · MPI3KD in complex with 5D · 74F A1101 · binds THR750, MET752, TRP760, ILE777, LYS779, TYR813, ILE825, GLU826 and 7 more

Residues it binds most

ILE 4, MET 4, THR 4, VAL 4, ASP 4, LYS 4, GLU 4, TRP 4, TYR 3, ALA 2 (residue and the binding sites it lines).

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