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Ligand · 6Z3

6Z3 · (2~{S},4~{R})-1-[(2~{S})-2-[(1-cyanocyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide

6Z3, (2~{S},4~{R})-1-[(2~{S})-2-[(1-cyanocyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide (C27 H33 N5 O4 S, 523.6 g/mol), in the MolNFT structures on…

Component
6Z3
Formula
C27 H33 N5 O4 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

6Z3 in 2 structures; the first of them:

  • 5LLI · pVHL:EloB:EloC in complex with VH298 · 6Z3 C301 · binds ASN67, ARG69, PHE76, PRO86, TRP88, PHE91, TYR98, PRO99 and 9 more
  • 5LLI · PVHL:ELOB:ELOC in complex with VH298 · 6Z3 C301 · binds ASN67, ARG69, PHE76, PRO86, TRP88, PHE91, TYR98, PRO99 and 9 more

Residues it binds most

ARG 8, HIS 8, PHE 8, PRO 8, TRP 8, TYR 8, ASN 8, ILE 8, LEU 8, SER 8 (residue and the binding sites it lines).

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