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Ligand · 6YN

6YN · ~{N}-[4-[(3~{S})-3-azanylpiperidin-1-yl]pyridin-3-yl]-2-[2,6-bis(fluoranyl)phenyl]imidazo[1,5-b]pyridazin-7-amine

6YN, ~{N}-[4-[(3~{S})-3-azanylpiperidin-1-yl]pyridin-3-yl]-2-[2,6-bis(fluoranyl)phenyl]imidazo[1,5-b]pyridazin-7-amine (C22 H21 F2 N7, 421.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding…

Component
6YN
Formula
C22 H21 F2 N7
Class
ligand
Structures
2
PDB entries
1

Binding sites

6YN in 2 structures; the first of them:

  • 5KZI · Crystal structure of human Pim-1 kinase in complex with an imidazopyridazine inhibitor. · 6YN A401 · binds LEU44, GLY45, PHE49, VAL52, ALA65, LYS67, ILE104, LEU120 and 9 more
  • 5KZI · Crystal structure of human pim-1 kinase in complex with an imidazopyridazine inhibitor. · 6YN A401 · binds LEU44, PHE49, VAL52, ALA65, LYS67, ILE104, LEU120, GLU121 and 7 more

Residues it binds most

LEU 2, ASP 2, GLU 2, ILE 2, VAL 2, ALA 2, ARG 2, LYS 2, PHE 2, ASN 1 (residue and the binding sites it lines).

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