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Ligand · 6ON

6ON · 2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6), 4,7,10,12-pentaen-9-yl]-~{N}-[2-[2-[2-[2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]et hoxy]ethoxy]ethyl]ethanamide

6ON, 2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6), 4,7,10,12-pentaen-9-yl]-~{N}-[2-[2-[2-[2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatr…

Component
6ON
Formula
C54 H66 Cl2 N10 O9 S2
Class
ligand
Structures
2
PDB entries
1

Binding sites

6ON in 2 structures; the first of them:

  • 5JWM · Bivalent BET Bromodomain Inhibition · 6ON A501 · binds ALA371, TRP374, PRO375, PHE376, VAL380, LEU385, LEU387, CYS429 and 21 more
  • 5JWM · Bivalent bet bromodomain inhibition · 6ON A501 · binds ALA371, TRP374, PRO375, PHE376, VAL380, LEU385, LEU387, CYS429 and 21 more

Residues it binds most

LEU 2, VAL 2, ALA 2, ASN 2, CYS 2, GLU 2, HIS 2, MET 2, PHE 2, PRO 2 (residue and the binding sites it lines).

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