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Ligand · 6AP

6AP · 9H-purine-2,6-diamine

6AP, 9H-purine-2,6-diamine (C5 H6 N6, 150.1 g/mol), in the MolNFT structures on GenesisL1: bound in 10 records (5 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
6AP
Formula
C5 H6 N6
Class
ligand
Structures
10
PDB entries
5

Binding sites

6AP in 10 structures; the first of them:

  • 2B57 · Guanine Riboswitch C74U mutant bound to 2,6-diaminopurine · 6AP A91 · binds A21, U22, U47, C50, U51, A52, A73, U74 and 1 more
  • 4FEO · Crystal structure of the AU25A/A46G/C74U mutant xpt-pbuX guanine riboswitch aptamer… · 6AP B101 · binds A21, U22, U47, C50, U51, A52, A73, U74 and 1 more
  • 4FEP · Crystal structure of the A24U/U25A/A46G/C74U mutant xpt-pbuX guanine riboswitch aptamer… · 6AP B101 · binds A21, U22, U47, C50, U51, A52, A73, U74 and 1 more
  • 4LCP · Crytsal structure of NE0047 in complex with 2,6-diaminopurine · 6AP A202 · binds PHE48, ASN66, HIS77, GLU79, ALA109, GLU110, PRO111, CYS112 and 4 more
  • 4LVZ · Structure of the THF riboswitch bound to 2,6-diaminopurine · 6AP A101 · binds U7, A8, U35, G41, U42, G44, G78, C79
  • 2B57 · Guanine riboswitch C74U mutant bound to 2,6-diaminopurine · 6AP A91 · binds A21, U22, U47, C50, U51, A52, A73, U74 and 1 more
  • 4FEO · Crystal structure of the AU25A/A46G/C74U mutant xpt-pbux guanine riboswitch aptamer… · 6AP B101 · binds A21, U22, U47, C50, U51, A52, A73, U74 and 1 more
  • 4FEP · Crystal structure of the A24U/U25A/A46G/C74U mutant xpt-pbux guanine riboswitch aptamer… · 6AP B101 · binds A21, U22, U47, C50, U51, A52, A73, U74 and 1 more
  • 4LCP · Crytsal structure of NE0047 in complex with 2,6-diaminopurine · 6AP A202 · binds PHE48, ASN66, HIS77, GLU79, ALA109, GLU110, PRO111, CYS112 and 4 more
  • 4LVZ · Structure of the thf riboswitch bound to 2,6-diaminopurine · 6AP A101 · binds U7, A8, U35, G41, U42, G44, G78, C79

Residues it binds most

U 8, A 8, C 8, G 2, GLU 2, PHE 2, ALA 2, ASN 2, ASP 2, CYS 2 (residue and the binding sites it lines).

Found with

  • NCO · Cobalt hexammine(iii)
  • ZN · Zinc ion
  • ACT · Acetate ion

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