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Ligand · 63N

63N · N-{2-[1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1H-imidazo[4,5-c]pyridin-6-amine

63N, N-{2-[1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1H-imidazo[4,5-c]pyridin-6-amine (C19 H20 N8 O2 S, 424.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site…

Component
63N
Formula
C19 H20 N8 O2 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

63N in 2 structures; the first of them:

  • 5HIC · EGFR kinase domain mutant TMLR" with a imidazopyridinyl-aminopyrimidine inhibitor" · 63N A1102 · binds LEU718, GLY719, PHE723, VAL726, ALA743, LYS745, GLU762, MET766 and 11 more
  • 5HIC · EGFR kinase domain mutant "tmlr" with a imidazopyridinyl- aminopyrimidine inhibitor · 63N A1102 · binds LEU718, GLY719, PHE723, VAL726, ALA743, LYS745, GLU762, MET766 and 11 more

Residues it binds most

LEU 2, MET 2, GLY 2, ALA 2, ARG 2, ASN 2, ASP 2, CYS 2, GLN 2, GLU 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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