GL1X · GenesisL1 explorer

Ligand · 634

634 · N-[3-({2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)phenyl]propanamide

634, N-[3-({2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)phenyl]propanamide (C19 H19 N7 O2, 377.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its…

Component
634
Formula
C19 H19 N7 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

634 in 2 structures; the first of them:

  • 5HG8 · EGFR (L858R, T790M, V948R) in complex with N-[3-({2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-p… · 634 A9001 · binds LEU718, GLY719, VAL726, ALA743, CYS775, MET790, GLN791, LEU792 and 11 more
  • 5HG8 · EGFR (L858R, T790M, V948R) in complex with N-[3-({2-[(1-methyl-1H… · 634 A9001 · binds LEU718, GLY719, VAL726, ALA743, CYS775, MET790, GLN791, LEU792 and 11 more

Residues it binds most

LEU 2, CYS 2, GLY 2, MET 2, PHE 2, ALA 2, ARG 2, ASP 2, GLN 2, PRO 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • GOL · Glycerol

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