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Ligand · 60D

60D · 6-[[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]amino]-~{N}-(oxan-4-yl)-1-propan-2-yl-pyrrolo[3,2-c]pyridine-3-carboxamide

60D, 6-[[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]amino]-~{N}-(oxan-4-yl)-1-propan-2-yl-pyrrolo[3,2-c]pyridine-3-carboxamide (C26 H30 N8 O4 S, 550.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
60D
Formula
C26 H30 N8 O4 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

60D in 2 structures; the first of them:

  • 5HCY · EGFR kinase domain mutant TMLR" with 3-carboxamide azaindole compound 13" · 60D A1102 · binds LEU718, GLY719, PHE723, VAL726, ALA743, LYS745, GLU762, MET766 and 13 more
  • 5HCY · EGFR kinase domain mutant "tmlr" with 3-carboxamide azaindole compound 13 · 60D A1102 · binds LEU718, GLY719, PHE723, VAL726, ALA743, LYS745, GLU762, MET766 and 13 more

Residues it binds most

LEU 2, MET 2, GLY 2, PHE 2, ALA 2, ARG 2, ASN 2, ASP 2, CYS 2, GLN 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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