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Ligand · 5UZ

5UZ · 5-cyclopropyl-1-[3-[2-fluoranyl-3-[(2~{R})-2-propylpiperidin-1-yl]carbonyl-phenyl]phenyl]pyrazole-4-carboxylic acid

5UZ, 5-cyclopropyl-1-[3-[2-fluoranyl-3-[(2~{R})-2-propylpiperidin-1-yl]carbonyl-phenyl]phenyl]pyrazole-4-carboxylic acid (C28 H30 F N3 O3, 475.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding…

Component
5UZ
Formula
C28 H30 F N3 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

5UZ in 2 structures; the first of them:

  • 7P5K · Pyrazole Carboxylic Acid Inhibitors of KEAP1:NRF2 interaction · 5UZ A702 · binds TYR334, SER363, GLY364, ASN382, ARG415, ILE461, GLY462, PHE478 and 10 more
  • 7P5K · Pyrazole carboxylic acid inhibitors of KEAP1:NRF2 interaction · 5UZ A702 · binds TYR334, SER363, ARG415, GLY462, PHE478, ARG483, SER508, GLY509 and 6 more

Residues it binds most

SER 2, GLY 2, TYR 2, ARG 2, PHE 2, ALA 2, ASN 1, ILE 1 (residue and the binding sites it lines).

Found with

  • CL · Chloride ion

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