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Ligand · 5OP

5OP · (5E,13E)-11-hydroxy-9,15-dioxoprosta-5,13-dien-1-oic acid

5OP, (5E,13E)-11-hydroxy-9,15-dioxoprosta-5,13-dien-1-oic acid (C20 H30 O5, 350.4 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds…

Component
5OP
Formula
C20 H30 O5
Class
ligand
Structures
4
PDB entries
2

Binding sites

5OP in 4 structures; the first of them:

  • 1V3V · Crystal structure of leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin… · 5OP A1360 · binds TYR49, ILE52, CYS239, TYR245, MET248, TYR273, PRO257, GLU258 and 2 more
  • 2ZB4 · Crystal structure of human 15-ketoprostaglandin delta-13-reductase in complex with NADP… · 5OP A600 · binds TYR51, TYR64, ILE65, PHE99, TYR100, MET135, THR139, CYS253 and 3 more
  • 1V3V · Crystal structure of leukotriene B4 12- HYDROXYDEHYDROGENASE/15-oxo-prostaglandin… · 5OP A1360 · binds TYR49, ILE52, CYS239, TYR245, MET248, TYR273, PRO257, GLU258 and 2 more
  • 2ZB4 · Crystal structure of human 15-ketoprostaglandin delta-13- reductase in complex with NADP… · 5OP A600 · binds TYR51, TYR64, ILE65, PHE99, TYR100, MET135, THR139, CYS253 and 3 more

Residues it binds most

TYR 6, ILE 6, CYS 6, MET 6, GLU 4, PRO 4, LEU 2, PHE 2, THR 2, VAL 2 (residue and the binding sites it lines).

Found with

  • NAP · Nadp nicotinamide-adenine-dinucleotide phosphate
  • CL · Chloride ion
  • SO4 · Sulfate ion

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