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Ligand · 5N3

5N3 · ~{N}-(7-chloranyl-1~{H}-indazol-3-yl)-7,7-dimethyl-2-(1~{H}-pyrazol-4-yl)-5~{H}-furo[3,4-d]pyrimidin-4-amine

5N3, ~{N}-(7-chloranyl-1~{H}-indazol-3-yl)-7,7-dimethyl-2-(1~{H}-pyrazol-4-yl)-5~{H}-furo[3,4-d]pyrimidin-4-amine (C18 H16 Cl N7 O, 381.8 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site…

Component
5N3
Formula
C18 H16 Cl N7 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

5N3 in 2 structures; the first of them:

  • 5EDQ · EGFR kinase (T790M/L858R) with inhibitor compound 15… · 5N3 A1101 · binds LEU718, GLY719, PHE723, VAL726, ALA743, ILE744, LYS745, GLU762 and 9 more
  • 5EDQ · EGFR kinase (T790M/L858R) with inhibitor compound 15: ~{N}-(7… · 5N3 A1101 · binds LEU718, GLY719, PHE723, VAL726, ALA743, ILE744, LYS745, GLU762 and 9 more

Residues it binds most

LEU 2, MET 2, ILE 2, ALA 2, GLN 2, GLU 2, GLY 2, LYS 2, PHE 2, VAL 2 (residue and the binding sites it lines).

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