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Ligand · 5N0

5N0 · 3-({3-[(3-{[4-({4-[(4-{[4-({(2R)-2-amino-4-[(1-methyl-4-{[1-methyl-4-({1-methyl-4-[(1-methyl-1H-imidazole-2-carbonyl)amino]-1H-imidazole-2-carbonyl}amino)-1H-pyrrole-2-carbonyl]amino}-1H-pyrrole-2-carbonyl) amino]butanoyl}amino)-1-methyl-1H-imidazole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carbonyl)amino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}propyl)(methyl) amino]propyl}carbamoyl)benzoic acid

5N0, 3-({3-[(3-{[4-({4-[(4-{[4-({(2R)-2-amino-4-[(1-methyl-4-{[1-methyl-4-({1-methyl-4-[(1-methyl-1H-imidazole-2-carbonyl)amino]-1H-imidazole-2-carbonyl}amino)-1H-pyrrole-2-carbonyl]amino}-1H-pyrrole-2-carbonyl)…

Component
5N0
Formula
C64 H75 N23 O12
Class
ligand
Structures
10
PDB entries
5

Binding sites

5N0 in 10 structures; the first of them:

  • 7RIL · Crystal structure of hairpin polyamide Py-Im 1 bound to 5' CCTGACCAGG · 5N0 B101 · binds DT3, DG4, DA5, DC6, DC7, DA8, DG9, DT3 and 6 more
  • 7RIM · RNA polymerase II elongation complex with hairpin polyamide Py-Im 1, scaffold 1 · 5N0 T101 · binds DT8, DC9, DT10, DG11, DG12, DT13, DC14, DA15 and 14 more
  • 7RIP · RNA polymerase II elongation complex with hairpin polyamide Py-Im 1, scaffold 1 soaked… · 5N0 T101 · binds DC9, DT10, DG11, DG12, DT13, DC14, DA15, DT16 and 12 more
  • 7RIX · RNA polymerase II elongation complex with hairpin polyamide Py-Im 1, scaffold 2 · 5N0 T101 · binds DT10, DG11, DG12, DT13, DC14, DA15, DT16, DG6 and 11 more
  • 7RIY · RNA polymerase II elongation complex with hairpin polyamide Py-Im 1, scaffold 2 soaked… · 5N0 T101 · binds DT8, DC9, DT10, DG11, DG12, DT13, DC14, DA15 and 14 more
  • 7RIL · Crystal structure of hairpin polyamide py-im 1 bound to 5' cctgaccagg · 5N0 B101 · binds DT3, DG4, DA5, DC6, DC7, DA8, DG9, DT3 and 6 more
  • 7RIM · RNA polymerase II elongation complex with hairpin polyamide py-im 1, scaffold 1 · 5N0 T101 · binds DT8, DC9, DT10, DG11, DG12, DT13, DC14, DA15 and 14 more
  • 7RIP · RNA polymerase II elongation complex with hairpin polyamide py-im 1, scaffold 1 soaked… · 5N0 T101 · binds DT10, DG11, DG12, DT13, DC14, DA15, DT16, DG6 and 11 more
  • 7RIX · RNA polymerase II elongation complex with hairpin polyamide py-im 1, scaffold 2 · 5N0 T101 · binds DT10, DG11, DG12, DT13, DC14, DA15, DT16, DG6 and 9 more
  • 7RIY · RNA polymerase II elongation complex with hairpin polyamide py-im 1, scaffold 2 soaked… · 5N0 T101 · binds DT10, DG11, DG12, DT13, DC14, DA15, DT16, DG6 and 10 more

Residues it binds most

DG 10, DA 10, DT 10, DC 10, ARG 8, HIS 8, GLU 2 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • ZN · Zinc ion
  • PPV · Pyrophosphate
  • ACT · Acetate ion

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