Ligand · 5I4

5I4 · ~{N}-[3-[5-(2-azanylpyrimidin-4-yl)-2-[(3~{S})-morpholin-3-yl]-1,3-thiazol-4-yl]-2-fluoranyl-phenyl]-2,5-bis(fluoranyl)benzenesulfonamide

5I4, ~{N}-[3-[5-(2-azanylpyrimidin-4-yl)-2-[(3~{S})-morpholin-3-yl]-1,3-thiazol-4-yl]-2-fluoranyl-phenyl]-2,5-bis(fluoranyl)benzenesulfonamide (C23 H19 F3 N6 O3 S2, 548.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1…

Component: 5I4
Formula: C23 H19 F3 N6 O3 S2
Class: ligand
Structures: 2
PDB entries: 1

Binding sites

5I4 in 2 structures; the first of them:

7P3V · B-Raf V600E structure bound to a new inhibitor · 5I4 A801 · binds ILE463, GLY464, VAL471, ALA481, LYS483, LEU505, LEU514, LEU515 and 12 more
7P3V · B-RAF V600E structure bound to a new inhibitor · 5I4 A801 · binds ILE463, GLY464, VAL471, ALA481, LYS483, LEU505, LEU514, PHE516 and 10 more

Residues it binds most

ILE 4, PHE 4, LEU 4, GLY 4, VAL 4, ALA 4, ASP 4, CYS 4, GLN 4, LYS 4 (residue and the binding sites it lines).

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