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Ligand · 5EW

5EW · 6'-chloro-1,4-dimethyl-5'-(2-methyl-6-{[4-(methylamino)pyrimidin-2-yl]amino}-1H-indol-1-yl)-3,3'-bipyridin-2(1H)-one

5EW, 6'-chloro-1,4-dimethyl-5'-(2-methyl-6-{[4-(methylamino)pyrimidin-2-yl]amino}-1H-indol-1-yl)-3,3'-bipyridin-2(1H)-one (C26 H24 Cl N7 O, 486.0 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every…

Component
5EW
Formula
C26 H24 Cl N7 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

5EW in 2 structures; the first of them:

  • 5DSX · Crystal structure of Dot1L in complex with inhibitor CPD10… · 5EW A1002 · binds PHE131, TYR136, SER140, LEU143, VAL144, MET147, ASP161, GLY163 and 12 more
  • 5DSX · Crystal structure of DOT1L in complex with inhibitor CPD10 [6'-chloro… · 5EW A1002 · binds PHE131, TYR136, SER140, LEU143, VAL144, MET147, ASP161, GLY163 and 12 more

Residues it binds most

SER 4, VAL 4, PHE 4, TYR 4, ASN 4, ASP 4, GLY 4, LEU 4, MET 4 (residue and the binding sites it lines).

Found with

  • K · Potassium ion

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