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Ligand · 573

573 · 7-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-N-{[(2S)-2-hydroxypropyl]oxy}furo[3,2-c]pyridine-2-carboxamide

573, 7-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-N-{[(2S)-2-hydroxypropyl]oxy}furo[3,2-c]pyridine-2-carboxamide (C17 H14 F2 I N3 O4, 489.2 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site…

Component
573
Formula
C17 H14 F2 I N3 O4
Class
ligand
Structures
2
PDB entries
1

Binding sites

573 in 2 structures; the first of them:

  • 4MNE · Crystal structure of the BRAF:MEK1 complex · 573 A903 · binds ASN78, GLY79, GLY80, LYS97, ILE99, LEU115, LEU118, VAL127 and 13 more
  • 4MNE · Crystal structure of the BRAF:MEK1 complex · 573 A903 · binds ASN78, GLY79, GLY80, LYS97, ILE99, LEU115, LEU118, VAL127 and 13 more

Residues it binds most

GLY 8, LEU 10, ILE 8, MET 10, VAL 8, ASP 8, PHE 10, ASN 8, LYS 8, SER 8 (residue and the binding sites it lines).

Found with

  • ACP · Phosphomethylphosphonic acid adenylate ester
  • MG · Magnesium ion
  • CL · Chloride ion

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