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Ligand · 507

507 · 1-{3-[6-(tetrahydro-2H-pyran-4-ylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone

507, 1-{3-[6-(tetrahydro-2H-pyran-4-ylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone (C19 H20 N4 O2, 336.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5…

Component
507
Formula
C19 H20 N4 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

507 in 2 structures; the first of them:

  • 3OOM · Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine… · 507 A500 · binds VAL214, GLY215, TYR219, VAL222, ALA233, LYS235, LEU263, THR283 and 10 more
  • 3OOM · Crystal structure of the ACVR1 kinase domain in complex with the IMIDAZO[1,2-B]PYRIDAZINE… · 507 A500 · binds VAL214, GLY215, TYR219, VAL222, ALA233, LYS235, LEU263, THR283 and 10 more

Residues it binds most

ALA 2, GLY 2, HIS 2, LEU 2, LYS 2, TYR 2, VAL 2, ASN 2, ASP 2, SER 2 (residue and the binding sites it lines).

Found with

  • PO4 · Phosphate ion
  • EDO · 1,2-ethanediol

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