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Ligand · 4ZR

4ZR · (1R)-1-{6-({2-[(3S,4R)-3-fluoro-4-methoxypiperidin-1-yl]pyrimidin-4-yl}amino)-1-[(2S)-1,1,1-trifluoropropan-2-yl]-1H-imidazo[4,5-c]pyridin-2-yl}ethanol

4ZR, (1R)-1-{6-({2-[(3S,4R)-3-fluoro-4-methoxypiperidin-1-yl]pyrimidin-4-yl}amino)-1-[(2S)-1,1,1-trifluoropropan-2-yl]-1H-imidazo[4,5-c]pyridin-2-yl}ethanol (C21 H25 F4 N7 O2, 483.5 g/mol), in the MolNFT structures on GenesisL1: bound in 1…

Component
4ZR
Formula
C21 H25 F4 N7 O2
Class
ligand
Structures
1
PDB entries
1

Binding sites

4ZR in 1 structure; the first of them:

  • 5CAU · EGFR kinase domain mutant "tmlr" with compound 41B · 4ZR A1102 · binds LEU718, GLY719, PHE723, VAL726, ALA743, LYS745, GLU762, MET766 and 10 more

Residues it binds most

LEU 1, MET 1, CYS 1, GLY 1, ALA 1, ASP 1, GLN 1, GLU 1, LYS 1, PHE 1 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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