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Ligand · 4ZG

4ZG · N~2~-[2-methyl-2-(methylsulfonyl)propyl]-N~4~-[2-methyl-1-(propan-2-yl)-1H-imidazo[4,5-c]pyridin-6-yl]pyrimidine-2,4-diamine

4ZG, N~2~-[2-methyl-2-(methylsulfonyl)propyl]-N~4~-[2-methyl-1-(propan-2-yl)-1H-imidazo[4,5-c]pyridin-6-yl]pyrimidine-2,4-diamine (C19 H27 N7 O2 S, 417.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry).…

Component
4ZG
Formula
C19 H27 N7 O2 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

4ZG in 2 structures; the first of them:

  • 5CAO · EGFR kinase domain mutant TMLR" with compound 29" · 4ZG A1101 · binds LEU718, GLY719, PHE723, VAL726, ALA743, LYS745, MET766, CYS775 and 9 more
  • 5CAO · EGFR kinase domain mutant "tmlr" with compound 29 · 4ZG A1101 · binds LEU718, GLY719, PHE723, VAL726, ALA743, LYS745, MET766, CYS775 and 9 more

Residues it binds most

LEU 2, MET 2, GLY 2, ALA 2, ASN 2, ASP 2, CYS 2, GLN 2, LYS 2, PHE 2 (residue and the binding sites it lines).

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