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Ligand · 4Z8

4Z8 · 2,2-dimethyl-3-[(4-{[2-methyl-1-(propan-2-yl)-1H-imidazo[4,5-c]pyridin-6-yl]amino}pyrimidin-2-yl) amino]propanamide

4Z8, 2,2-dimethyl-3-[(4-{[2-methyl-1-(propan-2-yl)-1H-imidazo[4,5-c]pyridin-6-yl]amino}pyrimidin-2-yl) amino]propanamide (C19 H26 N8 O, 382.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding…

Component
4Z8
Formula
C19 H26 N8 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

4Z8 in 2 structures; the first of them:

  • 5CAL · EGFR kinase domain mutant TMLR" with compound 24" · 4Z8 A1101 · binds LEU718, PHE723, VAL726, ALA743, LYS745, CYS775, MET790, GLN791 and 9 more
  • 5CAL · EGFR kinase domain mutant "tmlr" with compound 24 · 4Z8 A1101 · binds LEU718, PHE723, VAL726, ALA743, LYS745, CYS775, MET790, GLN791 and 9 more

Residues it binds most

LEU 2, MET 2, ALA 2, ARG 2, ASN 2, ASP 2, CYS 2, GLN 2, GLY 2, LYS 2 (residue and the binding sites it lines).

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