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Ligand · 4YX

4YX · N-{2-[4-(2-aminoethyl)-4-methoxypiperidin-1-yl]pyrimidin-4-yl}-2-methyl-1-(propan-2-yl)-1H-imidazo[4,5-c]pyridin-6-amine

4YX, N-{2-[4-(2-aminoethyl)-4-methoxypiperidin-1-yl]pyrimidin-4-yl}-2-methyl-1-(propan-2-yl)-1H-imidazo[4,5-c]pyridin-6-amine (C22 H32 N8 O, 424.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every…

Component
4YX
Formula
C22 H32 N8 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

4YX in 2 structures; the first of them:

  • 5C8N · EGFR kinase domain mutant TMLR" with compound 23" · 4YX A1102 · binds LEU718, PHE723, VAL726, ALA743, LYS745, GLU762, MET766, CYS775 and 9 more
  • 5C8N · EGFR kinase domain mutant "tmlr" with compound 23 · 4YX A1102 · binds LEU718, PHE723, VAL726, ALA743, LYS745, GLU762, MET766, CYS775 and 9 more

Residues it binds most

LEU 2, MET 2, ALA 2, ASN 2, ASP 2, CYS 2, GLN 2, GLU 2, GLY 2, LYS 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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