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Ligand · 4YW

4YW · 2-methyl-N-{2-[4-(methylsulfonyl)piperidin-1-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1H-imidazo[4,5-c]pyridin-6-amine

4YW, 2-methyl-N-{2-[4-(methylsulfonyl)piperidin-1-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1H-imidazo[4,5-c]pyridin-6-amine (C20 H27 N7 O2 S, 429.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding…

Component
4YW
Formula
C20 H27 N7 O2 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

4YW in 2 structures; the first of them:

  • 5C8M · EGFR kinase domain mutant TMLR" with compound 17" · 4YW A1101 · binds LEU718, GLY719, PHE723, VAL726, ALA743, LYS745, GLU762, MET766 and 9 more
  • 5C8M · EGFR kinase domain mutant "tmlr" with compound 17 · 4YW A1101 · binds LEU718, GLY719, PHE723, VAL726, ALA743, LYS745, GLU762, MET766 and 9 more

Residues it binds most

LEU 2, MET 2, GLY 2, ALA 2, ASP 2, CYS 2, GLN 2, GLU 2, LYS 2, PHE 2 (residue and the binding sites it lines).

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