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Ligand · 4US

4US · 4-(2-chlorophenyl)-7-[(4-methylpiperazin-1-yl) carbonyl]-9H-carbazole-1-carboxamide

4US, 4-(2-chlorophenyl)-7-[(4-methylpiperazin-1-yl) carbonyl]-9H-carbazole-1-carboxamide (C25 H23 Cl N4 O2, 446.9 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within…

Component
4US
Formula
C25 H23 Cl N4 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

4US in 2 structures; the first of them:

  • 5BQ0 · Crystal structure of bruton agammaglobulinemia tyrosine kinase complexed with BMS-824171… · 4US A701 · binds LEU408, GLY409, THR410, GLY411, VAL416, ALA428, LYS430, THR474 and 8 more
  • 5BQ0 · Crystal structure of bruton agammaglobulinemia tyrosine kinase complexed with bms-824171… · 4US A701 · binds LEU408, GLY409, THR410, GLY411, VAL416, ALA428, LYS430, THR474 and 8 more

Residues it binds most

GLY 2, ALA 2, LEU 2, THR 2, ASN 2, CYS 2, GLU 2, LYS 2, MET 2, TYR 2 (residue and the binding sites it lines).

Found with

  • DMS · Dimethyl sulfoxide
  • EDO · 1,2-ethanediol

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