GL1X · GenesisL1 explorer

Ligand · 4PX

4PX · 3-(1-hydroxy-2-methylpropan-2-yl)-5-phenyl-3,5-dihydro-1H-imidazo[4,5-c][1,8]naphthyridine-2,4-dione

4PX, 3-(1-hydroxy-2-methylpropan-2-yl)-5-phenyl-3,5-dihydro-1H-imidazo[4,5-c][1,8]naphthyridine-2,4-dione (C19 H18 N4 O3, 350.4 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (3 PDB entries). Every binding site with its…

Component
4PX
Formula
C19 H18 N4 O3
Class
ligand
Structures
3
PDB entries
3

Binding sites

4PX in 3 structures; the first of them:

  • 4ZO5 · PDE10 complexed with 4-isopropoxy-2-(2-(3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2… · 4PX A803 · binds TYR514, HIS515, THR623, LEU625, ASP664, LEU665, SER667, VAL668 and 9 more
  • 5C2E · PDE10 complexed with6-chloro-N-[(2,4-dimethylthiazol-5-yl)methyl]-5-methyl-2-[2-(2-pyridyl… · 4PX A803 · binds TYR514, HIS515, THR623, LEU625, ASP664, LEU665, SER667, VAL668 and 8 more
  • 5DH4 · PDE10 complexed with 5-chloro-N-[(2,4-dimethylthiazol-5-yl)methyl]pyrazolo[1,5-a]pyrimidin… · 4PX A804 · binds TYR514, HIS515, THR623, LEU625, ASP664, LEU665, SER667, VAL668 and 10 more

Residues it binds most

LEU 3, PHE 3, THR 3, TYR 3, ALA 3, ASP 3, GLN 3, GLY 3, HIS 3, ILE 3 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • ZN · Zinc ion
  • 4Q0 · 2-{2-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-4-(propan-2-yloxy)-1H-isoindole-1,3(2H)-dione
  • 4Y1 · 6-chloro-N-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-5-methyl-2-[2-(pyridin-2-yl)ethoxy]pyrimidin-4-amine
  • 5AV · 5-chloro-N-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.