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Ligand · 4GF

4GF · N-{1-(4-cyclopropyl-2-fluorophenyl)-3-[1-(propan-2-yl)piperidin-4-yl]-1H-pyrazol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide

4GF, N-{1-(4-cyclopropyl-2-fluorophenyl)-3-[1-(propan-2-yl)piperidin-4-yl]-1H-pyrazol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide (C27 H30 F N7 O, 487.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry).…

Component
4GF
Formula
C27 H30 F N7 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

4GF in 2 structures; the first of them:

  • 4YP8 · Irak4-inhibitor co-structure · 4GF A501 · binds MET192, GLY193, GLU194, GLY195, VAL200, ALA211, LYS213, VAL246 and 15 more
  • 4YP8 · IRAK4-inhibitor co-structure · 4GF A501 · binds MET192, GLY193, GLU194, GLY195, VAL200, ALA211, LYS213, VAL246 and 15 more

Residues it binds most

GLY 8, VAL 8, MET 8, SER 8, TYR 8, ALA 8, ASP 8, GLU 8, ARG 8, ASN 8 (residue and the binding sites it lines).

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