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Ligand · 4FJ

4FJ · 1'-[7-fluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-yl]-6'-(morpholin-4-yl)-1',2,2',3,5,6-hexahydrospiro[pyran-4,3'-pyrrolo[3,2-b]pyridine]

4FJ, 1'-[7-fluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-yl]-6'-(morpholin-4-yl)-1',2,2',3,5,6-hexahydrospiro[pyran-4,3'-pyrrolo[3,2-b]pyridine] (C30 H30 F N5 O2, 511.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
4FJ
Formula
C30 H30 F N5 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

4FJ in 2 structures; the first of them:

  • 4FJZ · Crystal structure of PI3K-gamma in complex with pyrrolo-pyridine inhibitor 63 · 4FJ A1205 · binds LYS802, VAL803, MET804, PRO810, LEU811, TRP812, ILE831, LYS833 and 13 more
  • 4FJZ · Crystal structure of PI3K-gamma in complex with pyrrolo-pyridine inhibitor 63 · 4FJ A1205 · binds LYS802, VAL803, MET804, PRO810, LEU811, TRP812, ILE831, LYS833 and 13 more

Residues it binds most

ILE 2, LYS 2, MET 2, THR 2, VAL 2, ALA 2, ASP 2, GLU 2, LEU 2, PHE 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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