GL1X · GenesisL1 explorer

Ligand · 46F

46F · (2R)-4-(6-chloropyridazin-3-yl)-N-(4-methoxybenzyl)-1-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazine-2-carboxamide

46F, (2R)-4-(6-chloropyridazin-3-yl)-N-(4-methoxybenzyl)-1-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazine-2-carboxamide (C24 H23 Cl F3 N5 O5 S, 586.0 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every…

Component
46F
Formula
C24 H23 Cl F3 N5 O5 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

46F in 2 structures; the first of them:

  • 3QGF · Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase complex with… · 46F A602 · binds TYR191, GLY192, PHE193, TYR195, SER196, PRO197, ARG200, SER288 and 17 more
  • 3QGF · Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase complex with… · 46F A602 · binds TYR191, GLY192, PHE193, TYR195, SER196, PRO197, ARG200, SER288 and 17 more

Residues it binds most

TYR 4, ILE 4, SER 4, LEU 4, ALA 4, ARG 4, CYS 4, GLY 4, MET 4, PHE 4 (residue and the binding sites it lines).

Found with

  • 23E · (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid
  • SO4 · Sulfate ion

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