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Ligand · 3R0

3R0 · N-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-2-(1H-pyrazol-4-yl)-3H-imidazo[4,5-c]pyridin-6-amine

3R0, N-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-2-(1H-pyrazol-4-yl)-3H-imidazo[4,5-c]pyridin-6-amine (C19 H21 N9 O, 391.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its…

Component
3R0
Formula
C19 H21 N9 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

3R0 in 2 structures; the first of them:

  • 4RJ6 · EGFR kinase (T790M/L858R) with inhibitor compound 4 · 3R0 A1102 · binds LEU718, GLY719, SER720, PHE723, VAL726, ALA743, LYS745, GLU762 and 10 more
  • 4RJ6 · EGFR kinase (T790M/L858R) with inhibitor compound 4 · 3R0 A1102 · binds LEU718, GLY719, SER720, PHE723, VAL726, ALA743, LYS745, GLU762 and 10 more

Residues it binds most

LEU 2, MET 2, GLY 2, ALA 2, ASP 2, GLN 2, GLU 2, LYS 2, PHE 2, PRO 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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