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Ligand · 3K5

3K5 · 3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2'S,3a'R,4''S,5''R,6'S,7a'S)-5''-methyl-4''-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3'-[1]benzofuran-2',2''-pyran]-6'-yl]carbonyl}-beta-D-glucopyranose

3K5, 3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2'S,3a'R,4''S,5''R,6'S,7a'S)-5''-methyl-4''-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3'-[1]benzofuran-2',2''-pyran]-6'-yl]carbonyl}-beta-D-gl…

Component
3K5
Formula
C40 H52 O17
Class
ligand
Structures
7
PDB entries
7

Binding sites

3K5 in 7 structures; the first of them:

  • 8C3A · Crystal structure of ailanthone bound to the Candida albicans 80S ribosome · 3K5 13403 · binds U2735, C2736, C2737, G2765, G2766, LYS40, TYR43, LYS55 and 3 more
  • 8CQ7 · Crystal structure of phyllanthoside bound to the Candida albicans 80S ribosome · 3K5 13401 · binds U2735, C2736, C2737, U2738, G2765, G2766, LYS40, TYR43 and 4 more
  • 8CRE · Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418 · 3K5 13402 · binds U2735, C2736, C2737, G2765, G2766, LYS40, TYR43, LYS55 and 3 more
  • 8OEQ · Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (250uM) · 3K5 13406 · binds U2735, C2736, C2737, U2738, G2765, G2766, GLY39, LYS40 and 5 more
  • 8OH6 · Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin… · 3K5 13463 · binds U2735, C2736, C2737, U2738, G2765, G2766, A2774, GLY39 and 6 more
  • 8OI5 · Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (2mM) · 3K5 13401 · binds U2735, C2736, C2737, U2738, G2765, G2766, LYS40, TYR43 and 4 more
  • 8OJ3 · Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418… · 3K5 13401 · binds U2735, C2736, C2737, G2765, G2766, A2774, GLY39, LYS40 and 5 more

Residues it binds most

C 13, G 13, LYS 13, U 13, GLN 13, ILE 13, PHE 13, TYR 13, A 7, GLY 6 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • ZN · Zinc ion
  • PAR · Paromomycin
  • GET · Geneticin
  • TIX · ailanthone

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