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Ligand · 3FR

3FR · 3'-chloro-5'-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)biphenyl-2-carboxamide

3FR, 3'-chloro-5'-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)biphenyl-2-carboxamide (C28 H24 Cl N5 O, 482.0 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site…

Component
3FR
Formula
C28 H24 Cl N5 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

3FR in 2 structures; the first of them:

  • 3DBD · Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain… · 3FR A313 · binds LEU45, GLY46, LYS47, GLY48, ALA51, LYS52, CYS53, ALA66 and 12 more
  • 3DBD · Crystal structure of an activated (thr->asp) polo-like kinase 1 (PLK1) catalytic domain… · 3FR A313 · binds LEU45, GLY46, LYS47, GLY48, ALA51, LYS52, CYS53, ALA66 and 12 more

Residues it binds most

GLY 2, LYS 2, ALA 2, ARG 2, CYS 2, GLU 2, LEU 2, ILE 2, PHE 2, SER 2 (residue and the binding sites it lines).

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