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Ligand · 373

373 · 3-(5-{[4-(aminomethyl)piperidin-1-yl]methyl}-1H-indol-2-yl)quinolin-2(1H)-one

373, 3-(5-{[4-(aminomethyl)piperidin-1-yl]methyl}-1H-indol-2-yl)quinolin-2(1H)-one (C24 H26 N4 O, 386.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5 Å, the…

Component
373
Formula
C24 H26 N4 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

373 in 2 structures; the first of them:

  • 2HXQ · crystal structure of Chek1 in complex with inhibitor 2 · 373 A324 · binds GLN13, THR14, LEU15, VAL23, ALA36, VAL68, LEU84, GLU85 and 6 more
  • 2HXQ · Crystal structure of CHEK1 in complex with inhibitor 2 · 373 A324 · binds GLN13, THR14, LEU15, VAL23, ALA36, VAL68, LEU84, GLU85 and 6 more

Residues it binds most

LEU 2, SER 2, VAL 2, ALA 2, CYS 2, GLN 2, GLU 2, GLY 2, THR 2, TYR 2 (residue and the binding sites it lines).

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