2Y9 · (3S,4R,5R)-N-cyclopropyl-N'-[(2R)-1-ethoxy-4-methylpentan-2-yl]-4-hydroxy-N-[5-(propan-2-yl)pyridin-2-yl]piperidine-3,5-dicarboxamide

Binding sites

2Y9 in 2 structures; the first of them:

• 4Q1N · Structure-based design of 4-hydroxy-3,5-substituted piperidines as direct renin inhibitors · 2Y9 A404 · binds GLN13, ASP32, GLY34, SER35, LEU73, ARG74, TYR75, SER76 and 14 more
• 4Q1N · Structure-based design of 4-hydroxy-3,5-substituted piperidines as direct renin inhibitors · 2Y9 A404 · binds GLN13, ASP32, GLY34, SER35, LEU73, ARG74, TYR75, SER76 and 14 more

Residues it binds most

LEU 4, ALA 4, ASP 4, GLY 4, ILE 4, PHE 4, SER 4, THR 4, ARG 4, PRO 4 (residue and the binding sites it lines).

Found with

• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
• PO4 · Phosphate ion
• DMS · Dimethyl sulfoxide