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Ligand · 2U5

2U5 · 6-{[(3R,5R,6S)-1-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl}pyridine-3-carboxylic acid

2U5, 6-{[(3R,5R,6S)-1-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl}pyridine-3-carboxylic acid (C34 H38 Cl2 N2 O5 S, 657.6 g/mol), in the MolNFT structures on…

Component
2U5
Formula
C34 H38 Cl2 N2 O5 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

2U5 in 2 structures; the first of them:

  • 4OGN · Co-Crystal Structure of MDM2 with Inhbitor Compound 3 · 2U5 A201 · binds VAL14, THR15, THR16, GLN18, LEU54, LEU57, GLY58, ILE61 and 11 more
  • 4OGN · Co-crystal structure of MDM2 with inhbitor compound 3 · 2U5 A201 · binds VAL14, THR15, THR16, GLN18, LEU54, LEU57, GLY58, ILE61 and 11 more

Residues it binds most

VAL 2, HIS 2, ILE 2, LEU 2, PHE 2, THR 2, TYR 2, GLN 2, GLY 2, LYS 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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