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Ligand · 2U0

2U0 · (2-{[(3R,5R,6S)-1-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl}-1,3-thiazol-5-yl)acetic acid

2U0, (2-{[(3R,5R,6S)-1-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl}-1,3-thiazol-5-yl)acetic acid (C33 H37 Cl2 F N2 O5 S2, 695.7 g/mol), in the MolNFT…

Component
2U0
Formula
C33 H37 Cl2 F N2 O5 S2
Class
ligand
Structures
2
PDB entries
1

Binding sites

2U0 in 2 structures; the first of them:

  • 4ODE · Co-Crystal Structure of MDM2 with Inhibitor Compound 4 · 2U0 A201 · binds MET6, VAL8, VAL14, THR15, THR16, GLN18, LEU54, LEU57 and 12 more
  • 4ODE · Co-crystal structure of MDM2 with inhibitor compound 4 · 2U0 A201 · binds MET6, VAL8, VAL14, THR15, THR16, GLN18, LEU54, LEU57 and 12 more

Residues it binds most

VAL 2, GLN 2, HIS 2, ILE 2, LEU 2, MET 2, THR 2, TYR 2, GLY 2, LYS 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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