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Ligand · 2TZ

2TZ · [(2R,5R,6R)-4-[(2S)-1-(tert-butylsulfonyl)butan-2-yl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid

2TZ, [(2R,5R,6R)-4-[(2S)-1-(tert-butylsulfonyl)butan-2-yl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid (C26 H31 Cl2 N O6 S, 556.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry).…

Component
2TZ
Formula
C26 H31 Cl2 N O6 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

2TZ in 2 structures; the first of them:

  • 4OCC · co-crystal structure of MDM2(17-111) in complex with compound 48 · 2TZ A201 · binds LEU54, PHE55, LEU57, GLY58, GLN59, ILE61, MET62, TYR67 and 10 more
  • 4OCC · Co-crystal structure of MDM2(17-111) in complex with compound 48 · 2TZ A201 · binds LEU54, PHE55, LEU57, GLY58, GLN59, ILE61, MET62, TYR67 and 10 more

Residues it binds most

ILE 6, PHE 6, LEU 6, TYR 6, GLN 6, GLY 6, HIS 6, LYS 6, MET 6, VAL 6 (residue and the binding sites it lines).

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