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Ligand · 2SF

2SF · 4-(3-{4-[(R)-amino(cyclopentyl)phenylmethyl]piperidin-1-yl}propoxy)benzonitrile

2SF, 4-(3-{4-[(R)-amino(cyclopentyl)phenylmethyl]piperidin-1-yl}propoxy)benzonitrile (C27 H35 N3 O, 417.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5 Å…

Component
2SF
Formula
C27 H35 N3 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

2SF in 2 structures; the first of them:

  • 4OG8 · Human menin with bound inhibitor MIV-6R · 2SF A602 · binds SER155, LEU177, SER178, GLU179, ASP180, HIS181, PHE238, CYS241 and 10 more
  • 4OG8 · Human menin with bound inhibitor miv-6R · 2SF A602 · binds SER155, LEU177, SER178, GLU179, ASP180, HIS181, PHE238, CYS241 and 10 more

Residues it binds most

ALA 2, GLU 2, MET 2, SER 2, TYR 2, ASP 2, CYS 2, GLY 2, HIS 2, LEU 2 (residue and the binding sites it lines).

Found with

  • PGA · 2-phosphoglycolic acid
  • TBF · Tert-butyl formate
  • SO4 · Sulfate ion
  • DMS · Dimethyl sulfoxide
  • PG4 · Tetraethylene glycol

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