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Ligand · 2RC

2RC · [6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate

2RC, [6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate (C23 H26 F N6 O9 P, 580.5 g/mol), in the MolNFT structures on GenesisL1…

Component
2RC
Formula
C23 H26 F N6 O9 P
Class
ligand
Structures
2
PDB entries
1

Binding sites

2RC in 2 structures; the first of them:

  • 4O75 · Crystal structure of the first bromodomain of human BRD4 in complex with FOSTAMATINIB · 2RC A201 · binds TRP81, PRO82, PHE83, GLN85, VAL87, LYS91, LEU92, LEU94 and 4 more
  • 4O75 · Crystal structure of the first bromodomain of human BRD4 in complex with fostamatinib · 2RC A201 · binds TRP81, PRO82, PHE83, GLN85, VAL87, LYS91, LEU92, LEU94 and 4 more

Residues it binds most

LEU 2, TYR 2, ASN 2, GLN 2, ILE 2, LYS 2, PHE 2, PRO 2, TRP 2, VAL 2 (residue and the binding sites it lines).

Found with

  • EDO · 1,2-ethanediol

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