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Ligand · 2QH

2QH · (8R)-3,3-difluoro-8-[4-fluoro-3-(pyridin-3-yl)phenyl]-8-(4-methoxy-3-methylphenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine

2QH, (8R)-3,3-difluoro-8-[4-fluoro-3-(pyridin-3-yl)phenyl]-8-(4-methoxy-3-methylphenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine (C25 H22 F3 N5 O, 465.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
2QH
Formula
C25 H22 F3 N5 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

2QH in 2 structures; the first of them:

  • 4NY4 · Crystal structure of CYP3A4 in complex with an inhibitor · 2QH A602 · binds ARG105, ARG106, PHE108, SER119, ILE120, ARG212, PHE213, PHE215 and 8 more
  • 4NY4 · Crystal structure of CYP3A4 in complex with an inhibitor · 2QH A602 · binds ARG105, ARG106, PHE108, SER119, ILE120, ARG212, PHE213, PHE215 and 8 more

Residues it binds most

PHE 2, ARG 2, ILE 2, ALA 2, GLU 2, SER 2, THR 2 (residue and the binding sites it lines).

Found with

  • HEM · Protoporphyrin IX containing Fe

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