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Ligand · 2KL

2KL · 2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-ylethoxy)phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide

2KL, 2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-ylethoxy)phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide (C21 H23 Cl2 N5 O2 S, 480.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site…

Component
2KL
Formula
C21 H23 Cl2 N5 O2 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

2KL in 2 structures; the first of them:

  • 2WI7 · Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone · 2KL A1224 · binds ASN51, SER52, ALA55, LYS58, ASP93, ILE96, GLY97, MET98 and 8 more
  • 2WI7 · Orally active 2-amino thienopyrimidine inhibitors of the HSP90 chaperone · 2KL A1224 · binds ASN51, SER52, ALA55, LYS58, ASP93, ILE96, GLY97, MET98 and 8 more

Residues it binds most

ASP 2, GLY 2, ILE 2, ALA 2, ASN 2, LEU 2, LYS 2, MET 2, PHE 2, SER 2 (residue and the binding sites it lines).

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