Ligand · 2K8

2K8 · (6R)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridine-6-carboxylic acid

2K8, (6R)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridine-6-carboxylic acid (C7 H9 N5 O3, 211.2 g/mol), in the MolNFT structures on GenesisL1: bound in 8 records (4 PDB entries). Every binding site with its residues within 4.5 Å, the residues…

Component: 2K8
Formula: C7 H9 N5 O3
Class: ligand
Structures: 8
PDB entries: 4

Binding sites

2K8 in 8 structures; the first of them:

4NJH · Crystal Structure of QueE from Burkholderia multivorans in complex with AdoMet and… · 2K8 A303 · binds PHE9, THR11, LEU12, GLN13, GLY14, GLU15, PHE25, ARG27 and 6 more
4NJI · Crystal Structure of QueE from Burkholderia multivorans in complex with AdoMet… · 2K8 A303 · binds THR11, LEU12, GLN13, GLY14, GLU15, PHE25, ARG27, THR90 and 3 more
4NJJ · Crystal Structure of QueE from Burkholderia multivorans in complex with AdoMet… · 2K8 A303 · binds THR11, LEU12, GLN13, GLY14, GLU15, PHE25, ARG27, THR90 and 4 more
4NTM · QueD soaked with sepiapterin (selenomethionine substituted protein) · 2K8 A202 · binds HIS16, LEU18, CYS27, HIS31, HIS33, THR84, SER85, GLU86 and 7 more
4NJH · Crystal structure of quee from burkholderia multivorans in complex with adomet and… · 2K8 A303 · binds PHE9, THR11, LEU12, GLN13, GLY14, GLU15, PHE25, ARG27 and 6 more
4NJI · Crystal structure of quee from burkholderia multivorans in complex with adomet… · 2K8 A303 · binds THR11, LEU12, GLN13, GLY14, GLU15, PHE25, ARG27, THR90 and 3 more
4NJJ · Crystal structure of quee from burkholderia multivorans in complex with adomet… · 2K8 A303 · binds THR11, LEU12, GLN13, GLY14, GLU15, PHE25, ARG27, THR90 and 4 more
4NTM · Qued soaked with sepiapterin (selenomethionine substituted protein) · 2K8 A202 · binds HIS16, LEU18, CYS27, HIS31, HIS33, THR84, SER85, GLU86 and 7 more

Residues it binds most

HIS 24, GLU 24, THR 24, LEU 24, PHE 24, GLY 12, ARG 12, ASP 12, CYS 12, GLN 12 (residue and the binding sites it lines).

Found with

SAM · S-adenosylmethionine
SF4 · Iron/sulfur cluster
NA · Sodium ion
PO4 · Phosphate ion
MG · Magnesium ion
MN · Manganese (II) ion
ZN · Zinc ion

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