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Ligand · 2H1

2H1 · 3-[2-(benzyloxy)-8-methylquinolin-6-yl]-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

2H1, 3-[2-(benzyloxy)-8-methylquinolin-6-yl]-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (C25 H24 N6 O, 424.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues…

Component
2H1
Formula
C25 H24 N6 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

2H1 in 2 structures; the first of them:

  • 4N4S · A Double Mutant Rat Erk2 in Complex With a Pyrazolo[3,4-d]pyrimidine Inhibitor · 2H1 A401 · binds ILE29, GLY30, TYR34, VAL37, ALA50, LYS52, ILE54, THR66 and 15 more
  • 4N4S · A double mutant rat ERK2 in complex with a PYRAZOLO[3,4-D]PYRIMIDINE inhibitor · 2H1 A401 · binds ILE29, GLY30, TYR34, VAL37, ALA50, LYS52, ILE54, THR66 and 15 more

Residues it binds most

ILE 4, LEU 4, GLU 4, ALA 4, ASP 4, LYS 4, GLY 4, MET 4, TYR 4, VAL 4 (residue and the binding sites it lines).

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