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Ligand · 2F5

2F5 · 1H-benzimidazol-2-yl(4-{[3-(morpholin-4-yl)pyrazin-2-yl]oxy}phenyl)methanone

2F5, 1H-benzimidazol-2-yl(4-{[3-(morpholin-4-yl)pyrazin-2-yl]oxy}phenyl)methanone (C22 H19 N5 O3, 401.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5 Å, the…

Component
2F5
Formula
C22 H19 N5 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

2F5 in 2 structures; the first of them:

  • 4MVH · Crystal Structure of PDE10A with Novel Keto-Benzimidazole Inhibitor · 2F5 A1010 · binds TYR514, HIS515, LEU625, LEU665, SER667, VAL668, ILE682, TYR683 and 9 more
  • 4MVH · Crystal structure of PDE10A with novel keto-benzimidazole inhibitor · 2F5 A1010 · binds TYR514, HIS515, LEU625, LEU665, SER667, VAL668, ILE682, TYR683 and 9 more

Residues it binds most

LEU 4, PHE 4, TYR 4, VAL 4, GLN 4, GLU 4, GLY 4, HIS 4, ILE 4, LYS 4 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • SO4 · Sulfate ion

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