GL1X · GenesisL1 explorer

Ligand · 20W

20W · (2S,3R,4R,5R)-N-(4-carbamoyl-2-methoxyphenyl)-2'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide

20W, (2S,3R,4R,5R)-N-(4-carbamoyl-2-methoxyphenyl)-2'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide (C29 H29 Cl2 F N4 O4 S, 619.5 g/mol), in the…

Component
20W
Formula
C29 H29 Cl2 F N4 O4 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

20W in 2 structures; the first of them:

  • 4LWV · The 2.3A Crystal Structure of Humanized Xenopus MDM2 with RO5545353 · 20W A201 · binds LEU50, LEU53, GLY54, ILE57, MET58, TYR63, HIS69, VAL71 and 9 more
  • 4LWV · The 2.3A crystal structure of humanized xenopus MDM2 with RO5545353 · 20W A201 · binds LEU50, LEU53, GLY54, ILE57, MET58, TYR63, HIS69, VAL71 and 9 more

Residues it binds most

HIS 6, ILE 6, LEU 6, PHE 6, TYR 6, VAL 6, LYS 6, GLY 6, MET 6, GLN 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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