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Ligand · 20U

20U · (2'S,3R,4'S,5'R)-N-(4-carbamoylphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide

20U, (2'S,3R,4'S,5'R)-N-(4-carbamoylphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide (C30 H29 Cl2 F N4 O3, 583.5 g/mol), in the MolNFT structures on…

Component
20U
Formula
C30 H29 Cl2 F N4 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

20U in 2 structures; the first of them:

  • 4LWU · The 1.14A Crystal Structure of Humanized Xenopus MDM2 with RO5499252 · 20U A201 · binds LEU50, LEU53, GLY54, ILE57, MET58, TYR63, HIS69, VAL71 and 7 more
  • 4LWU · The 1.14A crystal structure of humanized xenopus MDM2 with RO5499252 · 20U A201 · binds LEU50, LEU53, GLY54, ILE57, MET58, TYR63, HIS69, VAL71 and 7 more

Residues it binds most

HIS 2, ILE 2, LEU 2, PHE 2, TYR 2, VAL 2, GLY 2, LYS 2, MET 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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