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Ligand · 1TT

1TT · (8S)-9-[(5-chloranylpyridin-3-yl)methyl]-2-[(3R)-3-methylmorpholin-4-yl]-8-(trifluoromethyl)-6,7,8,9a-tetrahydro-3H-pyrimido[1,2-a]pyrimidin-4-one

1TT, (8S)-9-[(5-chloranylpyridin-3-yl)methyl]-2-[(3R)-3-methylmorpholin-4-yl]-8-(trifluoromethyl)-6,7,8,9a-tetrahydro-3H-pyrimido[1,2-a]pyrimidin-4-one (C19 H23 Cl F3 N5 O2, 445.9 g/mol), in the MolNFT structures on GenesisL1: bound in 2…

Component
1TT
Formula
C19 H23 Cl F3 N5 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

1TT in 2 structures; the first of them:

  • 4OYS · Crystal structure of VPS34 in complex with SAR405. · 1TT A905 · binds PHE612, SER614, PRO618, ILE634, LYS636, ASP644, TYR670, MET682 and 10 more
  • 4OYS · Crystal structure of VPS34 in complex with SAR405. · 1TT A905 · binds PHE612, SER614, PRO618, ILE634, LYS636, ASP644, TYR670, MET682 and 10 more

Residues it binds most

ASP 2, ILE 2, PHE 2, PRO 2, SER 2, GLN 2, LEU 2, LYS 2, MET 2, TYR 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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