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Ligand · 1OY

1OY · (3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-N-[(3S)-3,4-dihydroxybutyl]-5-(2,2-dimethylpropyl)-D-prolinamide

1OY, (3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-N-[(3S)-3,4-dihydroxybutyl]-5-(2,2-dimethylpropyl)-D-prolinamide (C27 H31 Cl2 F2 N3 O3, 554.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records…

Component
1OY
Formula
C27 H31 Cl2 F2 N3 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

1OY in 2 structures; the first of them:

  • 4JSC · The 2.5A crystal structure of humanized Xenopus MDM2 with RO5316533 - a pyrrolidine MDM2… · 1OY A201 · binds LEU50, LEU53, GLY54, ILE57, MET58, TYR63, HIS69, PHE82 and 6 more
  • 4JSC · The 2.5A crystal structure of humanized xenopus MDM2 with RO5316533 - a pyrrolidine MDM2… · 1OY A201 · binds LEU50, LEU53, GLY54, ILE57, MET58, TYR63, HIS69, PHE82 and 6 more

Residues it binds most

HIS 4, ILE 4, LEU 4, PHE 4, TYR 4, GLY 4, LYS 4, MET 4, VAL 4 (residue and the binding sites it lines).

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