Ligand · 1OO

1OO · N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}-4-(trifluoromethyl)benzenesulfonamide

1OO, N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}-4-(trifluoromethyl)benzenesulfonamide (C21 H11 Cl F5 N3 O3 S, 515.8 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every…

Component: 1OO
Formula: C21 H11 Cl F5 N3 O3 S
Class: ligand
Structures: 2
PDB entries: 1

Binding sites

1OO in 2 structures; the first of them:

4XV9 · B-Raf Kinase domain in complex with PLX5568 · 1OO A801 · binds ILE463, VAL471, ALA481, VAL482, LYS483, GLU501, LEU505, THR508 and 15 more
4XV9 · B-RAF kinase domain in complex with PLX5568 · 1OO A801 · binds ILE463, VAL471, ALA481, VAL482, LYS483, GLU501, LEU505, THR508 and 15 more

Residues it binds most

ILE 2, LEU 2, PHE 2, THR 2, VAL 2, ALA 2, ASP 2, CYS 2, GLN 2, GLU 2 (residue and the binding sites it lines).

Found with

SO4 · Sulfate ion

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