1JY · N-(4-{[(6S)-2-(hydroxymethyl)-4-oxo-4,6,7,8-tetrahydro-1H-cyclopenta[g]quinazolin-6-yl](prop-2-yn-1-yl)amino}benzoyl)-L-gamma-glutamyl-D-glutamic acid

Binding sites

1JY in 2 structures; the first of them:

• 4ISK · Crystal structure of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor · 1JY A303 · binds LYS48, HIS51, SER54, GLU58, THR78, ILE79, TRP80, TRP83 and 12 more
• 4ISK · Crystal structure of E.COLI thymidylate synthase with dump and the bgc 945 inhibitor · 1JY A303 · binds LYS48, HIS51, SER54, GLU58, THR78, ILE79, TRP80, TRP83 and 12 more

Residues it binds most

ILE 16, LEU 16, TRP 16, HIS 16, ASN 16, ALA 16, ASP 16, GLU 16, GLY 16, LYS 16 (residue and the binding sites it lines).

Found with

• UMC · 2'-deoxy-5'-uridylic acid
• UMP · 2'-deoxyuridine 5'-monophosphate
• MG · Magnesium ion